Abstracto

A convenient and green synthesis of (Z)-4-((1, 3-diphenyl-1Hpyrazol-4-yl) methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one promoted by L-proline

K.Veera Swamy, P.K.Dubey

A convenient and green synthesis of Z-4-((1,3-diphenyl-1H-pyrazol-4- yl)methylene)-1-phenylpyrazolin-5(4H)-one 6(a-h), promoted by L-proline is being reported. Two methods (A & B) have been established for the preparation of compounds 6(a-h). InmethodA, 1, 3-diphenyl-1H- pyrazole- 4-carbaldehyde 4(a-h) were treated with reactive pyrazolones 5 in the presence of L-proline and ethanol at roomtemperature under stirring for 15 min to afford 6(a-h). In method B, the 1,3-diphenyl-1H-pyrazolin-5-(4H)-4- carbaldehyde 4(a-h), pyrazolones 5 and L-proline were ground for 30 min. to afford 6(a-h).