Abstracto
A Facile Synthesis Of Rutaecarpine
Y.Lingam, Dipal R.Bhowmik, G.Srinivas, Aminul Islam, D.Muralimohan Rao
Total synthesis of rutaecarpine, a unique indoloquinazoline alkaloid from rutaceous plants, has been achieved from 2,3,4,9-tetrahydro-β-carbolin- 1-one. The key step is the Japp-Klingmann condensation between aniline and ethyl 2-[2-(1,3-dioxo-2,3- dihydro-1H-2-isoindolyl ethyl]-3- oxobutanoate.Treatment of 2,3,4,9-tetrahydro-β-carbolin-1-one with methyl anthranilate gives the rutaecarpine.
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