Abstracto

Computational Prediction of the Reactivity Sites of Alzheimer Amyloid b-Peptides Ab40 and Ab42

Juan Frau and Daniel Glossman-Mitnik


Alzheimer’s illness is an advanced nervous syndrome that is connected to the existence of extracellular senile plaques. The extracellular senile plaques are predominantly composed of 40-42 residues of amino acid comprising polypeptides identified as b-peptides. The Theory of Chemical Reactivity together with MEDT (Molecular Electron Density Theory) and Conceptual DFT have been used to determine descriptors that permitted the forecast of the sites of reactivity of the Alzheimer amyloidb-Peptides Ab40 and Ab42 through QM:MM calculations with the ONIOM methodology.


Indexado en

  • CAS
  • Google Académico
  • Abrir puerta J
  • Infraestructura Nacional del Conocimiento de China (CNKI)
  • CiteFactor
  • Cosmos SI
  • MIAR
  • Laboratorios secretos de motores de búsqueda
  • Pub Europeo
  • Universidad de Barcelona
  • ICMJE

Ver más

Flyer