Abstracto

Synthesis of some novel chromene derivatives

M.M.Kandeel, Aliaa.M.Kamal, Eman K.A.Abdelall, Heba A.H.Elshemy

2-Amino-4-aryl-7-alkoxy-4H-chromene-3-carbonitriles 2a&bwere intended to be used for the preparation of novel substituted triycyclic chromopyrimidine derivatives for their expected antitumor activity. Reaction of aminocyanochromenes with different carboxylic acids and their derivatives deemed to be the passage to those goal compounds yet unexpectedly 4-arylchrome-2-ones 4a&b and 6a&b and N,N- diacetyl aminocyanochromene 5a&b were resulted from the reaction of the aminocyanochromene 2a&b with the acids, acid chlorides and acetic anhydride sequentially this was proved using supporting evidence provided by single X-ray crystallography.