Abstracto

Addition of cyanide to aldehyide and ketons with hetropoly acid praysler.

Hassan hassani

We wish to report a novel and convenient one pot preparation of various cyanohydrin from carbonyl compounds with trimethylsily cyanide as a safer cyanating agent and readily available acid anhydride under the influence of a amount of praysler acid as a mild and efficient catalyst. By this method, aromatic and aliphatic aldehydes and ketones are converted into their corresponding cyanotrimethylsilyl ethers in excellent yields (85– 95%) in short reaction times (<30 min).