Abstracto

Cellulose sulphuric acid as an efficient catalyst for the synthesis of 5-arylidene-2,4-thiazolidinedione under microwave irradiation

K.F.Shelke

An efficient and solvent-free conditions for the synthesis of 5-arylidine- 2,4-thiazolidinediones by the Knoevenagel condensation of aromatic aldehydes with 2,4-thiazolidinedione in the presence of cellulose sulphuric acid (CSA) as a catalyst carried out under the influence ofmicrowave irradiation. The major advantages of this method are short reaction time, high yields and green aspects by avoiding toxic catalyst and hazardous solvent. Moreover, the CSA was successfully reused for four cycles without significant loss of activity.