Abstracto

Development and Validation of Spectrophotometeric Methods for the Estimation of Cefditoren Pivoxil

S. Appala Raju, Arvind B. Karadi and Shobha Manjunath


Three simple sensitive and economical spectrophotometric methods (A, B and C) for the quantitative estimation of cefditoren pivoxil in bulk drug and pharmaceutical dosage from have been developed. Method-A is based on UV absorption of drug in 0.1 N hydrocholoric acid exhibiting absorption maximum at 233 nm and it obyes Beer’s law in the concentration range of 1 to 5 μg/mL. Method-B (MBTH) is based on oxidation followed by coupling reaction of cefditoren pivoxil with 3- methyl-2-benzothiazolinone hydrazone (MBTH) in presence of ferric chloride to form purple coloured chromogen with absorption maxima max at 435 nm and obeyed Beer’s Law in the concentration range of 5-25 μg/mL. Method-C is based on the reaction of drug with folin-ciocalteau (FC) reagent in alkaline condition to from a stable blue coloured chromogen with absorption maximum at 760 nm and obeyed Beer’s law in the concentration range of 4 to 20 μg/mL. The results of the analysis for the three methods have been validated statically and by recovery studies. These method have been successfully extended to the pharmaceutical preparations (tablets) containing cefditoren.


Descargo de responsabilidad: este resumen se tradujo utilizando herramientas de inteligencia artificial y aún no ha sido revisado ni verificado.

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