Abstracto

Microwave Induced Synthesis and Antimicrobial Activities of Some Substituted Chalcones and their Pyrazoline and Isoxazolines Derivatives

Bhupendra Kumar Sharma, Vijay Kumar Dwivedi, Suresh C. Ameta and Deepika Rao

Condensation of acetone with subs tituted benzaldehyde in presence of some basic alumina under microwave irradiation affords 1, 5-substituted diphenyl-1, 4-pentadiende-3-one chalcones. These chalcones undergo facile and clean cyc lization with hydrazine RNHNH 2 (R= Ph, C 6 H 4 (NO 2 ) 2 , CONH 2 , CSNH 2 ) under microwave irradiation to afford 3, 5-ar ylated 2-pyrazolines in quantitative yields. The cyclocondensation of chalcones prepared with hydroxylamine hydrochloride resulted in the formation of isoxazoline derivatives. The structures of all the compounds have been established on the basis of analytical and spectral data. All the compounds have screened for antibacterial and antifungal activity. The results obtained indicate that, unlike classical heatin g, microwave irradiation results in higher yields, shorter reaction ti mes and cleaner reactions.