Abstracto

Potent antidyslipidemic property in gedunin from the fruits of Xylocarpus granatum

Vijai Lakshmi, Anju Puri

The ocean offers a rich source of structurally unique molecules providing novel plate form for drug discovery. The 50% aqueous ethanol extract of the epicarp of the fruits of X.granatum given orally at a dose of 500mg/kg showed significant antidyslipidemic activity in hamster model. Among the four fractions tested the chloroform soluble fraction showed highly significant lipid lowering activity at 50mg/kg. Further purification of chloroform fraction yielded four compounds. Out of four compounds bioevaluated, only one compound gedunin showed promising activity even at 25mg/kg. dose.