Abstracto

Simple Spectrophotometric Method for Determination of Quetiapine Fumarate in Tablets

G. Srihari and I. E. Chakravarthi

A simple, fast and reliable spectrophotometric method was developed for determination of quetiapine fumarate in pharmaceutical formulations.The methods is based on the reaction of quetiapine fumarate with wool fast blue, the formed ion pair complex extracted into chloroform at pH 1.5. The chloroform extractable layer is measured at 585 nm against reagent blank. The method is validated statistically.