Abstracto

Spectrophotometric methods for the estimation of cinitapride and pantoprazole in bulk and oral dosage form

P.V.Hemalatha, A.Jerad Suresh, V.Niraimathi

Different UV spectrophotometric methods have been developed for the estimation of cinitapride (CNP) and pantoprazole (PNP) in both bulk and capsule dosage form. Both the drugs were well soluble in methanol. CNP and PNP showed maximum absorption at 262nm and 290nm respectively using methanol as solvent. CNP obeyed BeerÂ’s law, showing linearity in the range of 4-20and PNP at 5-30µg/ml with correlation coefficient of 1 for both. Method A is based on standard absorbance, method B involves determination of theArea under curve (AUC) and method C makes use of second derivative of the Zero order spectrum. The developed methods were analyzed for specificity, limit of detection (LOD), limit of quantification (LOQ), linearity of response, precision and accuracy. Thus the proposed method could be adopted for routine analysis of the formulation.