Abstracto

Stability indicatingmethods for determination of ziprasidone hydrochloride

Samah Sayed Abbas, Hala El-Sayed Zaazaa, Mohamed Refaat El-Ghobashy, Yasmin Mohammed Fayez, Soheir Abdel Fattah

This manuscript describes the development and validation of a quantitative analyticalmethod for determination of ZiprasidoneHydrochloride (ZIP) in pure form and pharmaceutical product using ratio subtraction, first derivative ratio, TLC-densitometry and multivariate calibration techniques. The proposed methods are accurate, precise, sensitive, and selective and can be used in quality control laboratories.