Abstracto

Surface charge comparison of liposome and TiO2

P.F.Lee, W.A.T.Wan Abdullah, Misni Misran

The effect of an applied magnetic field on suspended particles was investigated in order to understand the particles response towards the applied field. Two types of particleswere studied, namely titaniumdioxide (TiO2) sols and caprate-capric acid liposome. The electrophoretic mobility of both types of particles under various conditions was examined through zetasizer which uses principles of laser doppler velocimetry. To elucidate the effects of different temperature, voltages, and the different time lapse, meanwhile the ionic strengthmediumis fixed at pH 7. Theoretically, higher temperature would increase the kinetic energy of the particles, thus increasing the electrophoreticmobility. Both the electrophoretic mobility of particles demonstrated a proportional relation with temperature. The comparison between TiO2 and liposome indicates that liposome elicited a greater electrophoretic mobility at higher temperature but had a lower migration rate as the applied voltage increased. For time lapse more than 10 s betweenmeasurements of the surface charge changes on the particles showed that TiO2migrated fastest at the longest time lapse of 120 swhichmight be due to the aggregation of TiO2 in solution. Meanwhile, the greatest zeta potential distribution of liposome was achieved at time lapse of 10s.