Abstracto

The effect of ethanol extract of Morinda tinctoria Roxb leaves on antiulcer activity in rats

R.Vadivu, V.Chitra, Susmitha, K.Sindhu, P.Muthusamy, L.Suseela

The main Objective of the study is to screen the antiulcer activity of ethanol extract of Morinda tinctoria Roxb leaves using different experimentally induced gastric ulcer models in rats. Gastric ulcer was induced in rats by pylorus ligation, 80% ethanol (1ml/ rat) and aspirin (200mg/kg). In pylorus ligation induced ulcer model the parameters studied were gastric volume, free acidity, total acidity and ulcer index. Lesion index and percentage inhibition of ulcer were determined in ethanol induced ulcermodel and in aspirin induced ulcer model the ulcer index was determined. In pylorus ligation model,MTE (Morinda tinctoria extract) pretreatment caused significant reduction in gastric volume, free acidity, total acidity and ulcer index as compared to control group. In ethanol induced and aspirin induced ulcers, MTE was effective in reducing the lesion index. The results suggest thatMTE posses significant (p0.001) antiulcer activity. Thismay be the presence of flavanoid in the plant.